The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.

The Chlamydia muridarum-Induced IFN-b Response Is TLR3-Dependent in Murine Oviduct Epithelial Cells

Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines.

Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the United States and a major cause of female infertility due to infection-induced Fallopian tube scarring. Epithelial cells are likely central to host defense and pathophysiology as they are the principal cell type productively infected by C. trachomatis. We generated cloned murine oviduct epithelial cell lines ...

Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells.

Because epithelial cells are the major cell type productively infected with Chlamydia during genital tract infections, the overall goal of our research was to understand the contribution of infected epithelial cells to the host defense. We previously showed that Toll-like receptor 3 (TLR3) is the critical pattern recognition receptor in oviduct epithelial (OE) cells that is stimulated during Ch...

Analyses of the Pathways Involved in Early- and Late-Phase Induction of IFN-Beta during C. muridarum Infection of Oviduct Epithelial Cells

We previously reported that the IFN-β secreted by Chlamydia muridarum-infected murine oviduct epithelial cells (OE cells) was mostly dependent on the TLR3 signaling pathway. To further characterize the mechanisms of IFN-β synthesis during Chlamydia infection of OE cells in vitro, we utilized specific inhibitory drugs to clarify the roles of IRF3 and NF-κB on both early- and late-phase C. murida...

Chlamydia Infection in Murine Oviduct Epithelial Cells

Identifying a Role for TLR3 in the Innate Immune Response to 1 Chlamydia Infection in Murine Oviduct Epithelial Cells 2 3 Wilbert A. Derbigny†, LaTasha R. Shobe, Jasmine C. Kamran, Katherine S. Toomey, and 4 Susan Ofner 5 Department of Microbiology and Immunology, Department of Medicine, Department of 6 Biostatistics; Indiana University School of Medicine 7 Indianapolis, Indiana 46202 8 9 10 11...